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Venlafaxine-related galactorrhea in an adolescent female: A case report

      Abstract

      Hyperprolactinemia with galactorrhea is a well-documented adverse effect of some psychotropic medications. While advanced practice psychiatric nurses are likely familiar with hyperprolactinemia with galactorrhea as an adverse effect of antipsychotics, they may be less familiar with hyperprolactinemia with galactorrhea associated with antidepressants, an adverse effect that is far less common. Advanced practice psychiatric nurses must be able to identify hyperprolactinemia and galactorrhea in patients and must be able to evaluate and manage antidepressant-related hyperprolactinemia with galactorrhea. Thus, this case report describes hyperprolactinemia with galactorrhea in a teenage female prescribed venlafaxine for the treatment of major depressive disorder and posttraumatic stress disorder. To our knowledge, this is the first case report that describes galactorrhea related to a reuptake inhibitor (SNRI) in an adolescent.

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      References

        • Alosaimi F.D.
        • Fallata E.O.
        • Abalhassan M.
        • Alhabbad A.
        • Alzain N.
        • Alhaddad B.
        • Alassiry M.Z.
        Prevalence and risk factors of hyperprolactinemia among patients with various psychiatric diagnoses and medications.
        International Journal of Psychiatry in Clinical Practice. 2018; 22: 274-281
        • Ayd M.B.
        Reversible normoprolactinemic galactorrhea in major depressive disorder with a stable dose of fluoxetine: A case report.
        Klinik Psikofarmakoloji Bulteni. 2019; 29: 179-180
        • Bangwal R.
        • Bisht S.
        • Saklani S.
        • Garg S.
        • Dhayani M.
        Psychotic disorders, definition, sign and symptoms, antipsychotic drugs, mechanism of action, pharmacokinetics & pharmacodynamics with side effects & adverse drug reactions: Updated systematic review article.
        Journal of Drug Delivery and Therapeutics. 2020; 10: 163-172
        • Camkurt M.A.
        • Gülpamuk G.
        • Fındiklı E.
        • Elve R.
        Dose dependent course of hyperprolactinemic and normoprolactinemic galactorrhea induced by venlafaxine.
        Clinical Psychopharmacology and Neuroscience. 2017; 15: 181
        • Check D.
        • Check J.H.
        • Dix E.
        Correction of normoprolactinemic galactorrhea following treatment with sympathomimetic amines.
        Fertility and Sterility. 2008; 89: S15
        • DeLeo V.
        • Cella S.G.
        • Camanni F.
        • Genazzani A.R.
        • Müller E.E.
        Prolactin lowering effect of amphetamine in normoprolactinemic subjects and in physiological and pathological hyperprolactinemia.
        Hormone and Metabolic Research. 1983; 15: 439-443
        • Glocker C.
        • Grohmann R.
        • Engel R.
        • Seifert J.
        • Bleich S.
        • Stübner S.
        • Schüle C.
        Galactorrhea during antipsychotic treatment: Results from AMSP, a drug surveillance program, between 1993 and 2015.
        European Archives of Psychiatry and Clinical Neuroscience. 2021; 271: 1425-1435
        • Gulsun M.
        • Algul A.
        • Semiz U.B.
        • Ates M.A.
        • Doruk A.
        • Ebrinc S.
        • Cetin M.
        A case with euprolactinemic galactorrhea induced by escitalopram.
        The International Journal of Psychiatry in Medicine. 2007; 37: 275-278
        • Levine S.
        • Muneyyirci-Delale O.
        Stress-induced hyperprolactinemia: pathophysiology and clinical approach.
        Obstetrics and Gynecology International. 2018; 2018
        • Luo T.
        • Liu Q.S.
        • Yang Y.J.
        • Wei B.
        Aripiprazole for the treatment of duloxetine induced hyperprolactinemia: A case report.
        Journal of Affective Disorders. 2019; 250: 330-332
        • Müller E.E.
        • Locatelli V.
        • Cella S.
        • Penalva A.
        • Novelli A.
        • Cocchi D.
        Prolactin lowering and-releasing drugs.
        Drugs. 1983; 25: 399-432
        • Navy H.
        • Gardner K.
        Strategies for managing medication-induced hyperprolactinemia.
        Current Psychiatry. 2018; 17: 42-47
        • Ouanes S.
        • Van der Vaeren B.
        • Cromec I.
        • Golay F.
        • Rey-Bellet P.
        Galactorrhea associated with sertraline: A case report and literature review.
        European Psychiatry. 2015; 30: 1
        • Özkan H.M.
        Galactorrhea and hyperprolactinemia during vortioxetine use: Case report.
        Turkish Journal of Biochemistry. 2019; 44: 105-107
        • Özkan H.M.
        Duloxetine associated galactorrhea and hyperprolactinemia: A case report.
        Turk Psikiyatri Dergisi. 2020; 31: 294
        • Somerall B.
        • William E.
        • D’Ann W.
        Hyperprolactinemia: The ABCs of diagnosis and management.
        Women's Healthcare. 2020;
        • Sternbach H.
        Venlafaxine-induced galactorrhea.
        Journal of Clinical Psychopharmacology. 2003; 23: 109-110
        • Suthar N.
        • Pareek V.
        • Nebhinani N.
        • Suman D.K.
        Galactorrhea with antidepressants: A case series.
        Indian Journal of Psychiatry. 2018; 60: 145
        • Vilar L.
        • Vilar C.F.
        • Lyra R.
        • da Conceicao Freitas M.
        Pitfalls in the diagnostic evaluation of hyperprolactinemia.
        Neuroendocrinology. 2019; 109: 7-19
        • Warren M.B.
        Venlafaxine-associated euprolactinemic galactorrhea and hypersexuality: A case report and review of the literature.
        Journal of Clinical Psychopharmacology. 2016; 36: 399-400
        • Wichman C.L.
        • Cunningham J.L.
        A case of venlafaxine-induced galactorrhea?.
        Journal of Clinical Psychopharmacology. 2008; 28: 580-581